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What Is A Safe Homocysteine Level?

While commercial blood test labs say "normal" homocysteine concentration in your blood can range from 5 to 15 micromoles per liter of blood, medical studies show that homocysteine levels above 6.3 are unhealthy and associated with a steep, progressive risk of coronary artery disease and heart attack.1

The average American's homocysteine level is 10, more than 50% above the low-risk threshold.2

Healthy homocysteine levels can be maintained with a combination of Folate, B12 and B6. The body-ready (conenzymated) form of these vitamins may help overcome obstacles to metabolizing homocysteine.

Homocysteine concentrations now widely accepted as normal are associated with increased likelihood of coronary artery disease, and this risk increases with rising homocysteine concentrations.1 Each 3-unit increase in homocysteine equal a 35% increase in heart attack risk.3

Plasma total homocysteine is a strong predictor of both cardiovascular and noncardiovascular mortality in a general population of 65-72 year olds. A homocysteine increment of 5 mmol/L has been associated with a 49% increase in all-cause mortality, a 50% increase in cardiovascular mortality, a 26% increase in cancer mortality, and a 104% increase in noncancer, noncardiovascular mortality.4


1Robinson K., et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995 Nov 15;92(10):2825-30.

2Andreotti F., et al. Homocysteine and arterial occlusive disease: a concise review. Cardiologia. 1999 Apr;44(4):341-5.

3Verhoef, MJ. Et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am. J. Epidemiol. 1996 143: 845-859.

4 Stein Emil Vollset, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study Am J Clin Nutr 2001 74: 130-136.

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