Is A Safe Homocysteine Level?
While commercial blood test labs say "normal" homocysteine concentration
in your blood can range from 5 to 15 micromoles per liter of blood,
medical studies show that homocysteine levels above 6.3 are unhealthy
and associated with a steep, progressive risk of coronary artery
disease and heart attack.1
American's homocysteine level is 10, more than 50% above the low-risk
Healthy homocysteine levels can be
maintained with a combination of Folate,
B12 and B6
. The body-ready (conenzymated) form of these
vitamins may help overcome obstacles to metabolizing homocysteine.
Homocysteine concentrations now widely accepted as normal
are associated with increased likelihood of coronary artery
disease, and this risk increases with rising homocysteine
concentrations.1 Each 3-unit increase in homocysteine
equal a 35% increase in heart attack risk.3
Plasma total homocysteine is a strong predictor of both cardiovascular
and noncardiovascular mortality in a general population of
65-72 year olds. A homocysteine increment of 5 mmol/L has
been associated with a 49% increase in all-cause mortality,
a 50% increase in cardiovascular mortality, a 26% increase
in cancer mortality, and a 104% increase in noncancer, noncardiovascular
Why Vitamins Might Not Protect You
Robinson K., et al. Hyperhomocysteinemia and low pyridoxal
phosphate. Common and independent reversible risk factors for coronary
artery disease. Circulation. 1995 Nov 15;92(10):2825-30.
Andreotti F., et al. Homocysteine and arterial occlusive disease: a concise review.
Cardiologia. 1999 Apr;44(4):341-5.
Verhoef, MJ. Et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am. J. Epidemiol. 1996 143: 845-859.
Stein Emil Vollset, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study Am J Clin Nutr 2001 74: 130-136.