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Let's Clear Up The Confusion:
Folic Acid versus Bioactive Folate

Even if your daily diet doesn't include 6-8 servings of fresh fruits and vegetables, you can still give your body the form of folate it prefers most. HS Fighters Active B Vitamins™ are made with BioAactiv Folate™ (an ingredient so unique, it's patented) --- the naturally occurring active form of folate you get every time you eat green leafy vegetables. Understanding the difference between Folic Acid and Bioactive Folate is important, so please continue reading...

Are You Converting Folic Acid to Active Folate?

Folic acid is often labeled folate or folicin. However, none of these are the active form of folate (known as L-5-MTHF or l-methylfolate) your body can absorb and put to work. It takes four separate biochemical reactions for your body to turn folic acid into active folate:

Absorption and conversion are critical. It is a shortage of active folate (and not folic acid, folate or folicin) that has been linked to neural tube birth defects in babies, vascular plaque, heart disease, depression, memory loss, Alzheimer's disease, and osteoporosis.

Medical studies have proven that the conversion of folic acid into active folate is frequently disrupted by genetic factors, age-related problems and metabolic obstacles.1,2

  • Up to 40% of adults are affected by genetic flaws that limit the amount of folic acid converted to the active folate that neutralizes homocysteine.3-10
  • Transformation of folic acid into active folate falls off after ingesting 200 mcg, and is saturated at doses in the region of 400 mcg. Higher doses result in unabsorbed folic acid circulating in the blood, and we do not know the long term biological effects of a lifetime of exposure to unmodified synthetic folate.1,10

Take More Folic Acid?

Some people try to overcome the obstacles to absorbing and transforming folic acid by taking doses of 800 mcgs, or higher. Studies show transformation of folic acid into active folate falls off after ingesting 200 mcg, and is saturated at doses in the region of 400 mcg. And when folic acid fails to be converted to active folate it remains in the bloodstream for days, even weeks at a time.1,10 Medical researchers are now investigating whether "unused" folic acid in the bloodstream actually blocks the absorption of folate from natural sources such as green leafy vegetables.


If testing your blood and cell tissue to confirm your active folate status doesn't thrill you, here's an intelligent alternative: let your body bypass the four-step conversion of folic acid by giving your body the exact form of folate it prefers and can immediately absorb -- the BioActive Folate in HS Fighters Active B Vitamins™.

The decision to exclude folic acid from the HS Fighters Active B VitaminsT formula, in favor of high-absorption BioActive Folate™, was made for these key reasons:

  • BioActiv Folate™ is the naturally occurring form of folate your body prefers
  • BioActiv Folate™ bypasses obstacles to absorbing folic acid and does not accumulate in the blood like folic acid
  • BioActiv Folate™ is so unique, the ingredient is protected under law by a U.S. Patent (as Metafolin®)
  • BioActiv Folate™ has been safety tested as a dietary ingredient and registered with the FDA (as Metafolin®)
  • BioActiv Folate™ is produced by a world leader in folate nutrition


1 Kelly P, McPartlin J, Goggins M, Weir DG, Soctt JM. Unmetabolozed folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr. 1997;65:1790-5>

2 Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yakazi Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor of coronary artery disease. Circulation 95:2032-2036, 1997.

3 Goyette P, Christensen B, Rosenblatt DS, Rozen R. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR0 gene, and description of 5 novel mutations in MTHFR. Am. J. Hum. Genet. 59:1268-1275, 1996.

4 Bailey LB,Gregory JF. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr 1999;129(5):919-22.

5 Deloughery TG, Evans A, Sadeghi A, et al. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease. Circulation 1996;94(12):3074-78.

6 Kim YI. Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev 2000;58:205-17.

7 Choi S-W, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000;130:129-32.

8 Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996;94(10):2410-16.

9 Miyao M, Morita H, Hosoi T, et al. Association of methylenetetrahydrofolate reductase(MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 2000;66:190-94.

10 Lucock MD, Wild J, Smithells R, Hartley R. Invivo characterization of the absorption and biotransformation of pteroylglutamic acid in man: a model for future studies. Biochem Med Metaab Biol 1989;42:30-42.

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These statements have not been evaluated by the Food And Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Metafolin® is a registered trademark of Merck KGaA.